A Cross Sectional Analysis of Hypothyroidism and Hyperthyroidism in Down Syndrome
Sandeep Sharma, Javid Khan, Chandrika Kondali
Abstract
Thyroid dysfunction (both hypo- and hyperthyroidism) is much more frequent in Down Syndrome. Hypothyroidism (reduced thyroid hormone production) and Hyperthyroidism (overproduction of thyroid hormones) are known to be more common in individuals with Down Syndrome. Hyperthyroidism shows reduced production of (thyroxine T4, triiodothyronine T3 and may affect Autoimmune mechanisms (immune dysregulation is common in DS). Hyperthyroidism is usually about overproduction of thyroxine (T4), less common than hypothyroidism in DS (~1–5%). Thyroid disorders can exacerbate behavioral, cognitive, and growth challenges in Down Syndrome. Timely detection and management is therefore essential. This research paper explores cross sectional analysis of Hypo and Hyper Thyroidism in Down Syndrome. It presents, identifies, examines and analyzes the prevalence of overt and subclinical hypothyroidism and hyperthyroidism in a cross-sectional sample of individuals with Down syndrome. It also identifies demographic and clinical predictors.
Keywords:
Hyperthyroidism, Hypothyroidism, Down Syndrome, Hypo and Hyperthyroidism in DS
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